Abstract Background Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities.Recently the MLIV gene, MCOLN1, has been identified as a new member of Storage Pier the transient receptor potential (TRP) cation channel superfamily.Here we report the cloning and
Baclofen, a GABA-B receptor agonist, is a promising treatment for alcohol use disorder (AUD).Its mechanism of action in this condition is unknown.GABA-B receptors interact with many biological systems potentially involved in AUD, including transduction pathways and neurotransmitter systems.Preclinical studies have shown that GABA-B receptors are in
In earlier papers, we presented a binary evolutionary code for the purpose of reproducing the orbital parameters, masses, radii, and location in the Hertzsprung Russell diagram (abbreviated as Car Mats HRD) of well-observed Algol systems.In subsequent versions, the effects of mass and angular momentum losses and tidal coupling were included in orde
This article focuses on exemplifying the features of discrimination phenomenon in the workplace, a phenomenon that has appeared in the Romanian social studies only in the last 4 years.Mobbing phenomenon has been analyzed by several countries in Europe such as England, France, Germany; after these RED analyzes it has been found that this phenomenon
Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by alveolar accumulation of Roper Saddle surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages.Mainstay of treatment is whole lung lavage, which requires general anesthesia.Herein, we report a case of Mastectomy Bras primary PAP,